Description

[6R-[6Alpha,7Beta(Z)]]-7-[2-Furyl(Methoxyimino)Acetamido]-3-(Hydroxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. It matters as a critical building block in the synthesis of third-generation cephalosporin antibiotics, enabling the production of potent antimicrobial agents. Pharmaceutical manufacturers and research institutions require this high-purity intermediate for developing and producing active pharmaceutical ingredients (APIs) to combat bacterial infections.

Application

• API Synthesis: Primary use as a crucial intermediate in the chemical synthesis of third-generation cephalosporin antibiotics.
• Pharmaceutical Research: Serves as a key starting material or intermediate in medicinal chemistry for developing new antimicrobial compounds.
• Antibiotic Production: Used in the commercial-scale manufacturing of specific cephalosporin drugs, contributing to global antibiotic supply chains.
• Process Development: Employed in R&D for optimizing synthetic routes and scaling up production processes for cephalosporin-based medicines.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.

Basic Information

Product Name	[6R-[6Alpha,7Beta(Z)]]-7-[2-Furyl(Methoxyimino)Acetamido]-3-(Hydroxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	56271-94-4
Molecular Formula	C17H17N3O7S
Molecular Weight	407.40 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Furyl)-2-(Methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefuroxime Axetil Intermediate; Cefuroxime Acid; (Z)-Isomer of Cefuroxime; 7-[2-(2-Furyl)-2-(Methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefuroxime Key Intermediate; CET Intermediate
EINECS	Contact for details

Quality Control

Our [6R-[6Alpha,7Beta(Z)]]-7-[2-Furyl(Methoxyimino)Acetamido]-3-(Hydroxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isomer content, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Isomer Content (Z-Isomer)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.