Description

(+)-Butaclamol CAS NO 56245-67-1 is a high-purity enantiomer of the potent neuroleptic agent butaclamol. This compound is of significant value in pharmaceutical research and development, particularly as a selective dopamine receptor antagonist. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for neuroscientific studies and the development of central nervous system (CNS) therapeutics. Key industries requiring this material include pharmaceutical R&D, contract research organizations (CROs), and academic institutions focused on neuropharmacology.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.
• Neuroscience Research: Acts as a potent tool compound for studying dopamine D1 and D2 receptor interactions and signal transduction pathways.
• Psychopharmacology Studies: Employed in preclinical research to investigate mechanisms of antipsychotic agents and model CNS disorders.
• Biochemical Assay Development: Serves as a key ligand in receptor binding assays and high-throughput screening (HTS) platforms.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and development of novel neuropsychiatric drug candidates.
• Metabolite Identification: Utilized as a parent compound in ADME (Absorption, Distribution, Metabolism, and Excretion) studies.

Basic Information

Product Name	(+)-Butaclamol
CAS No.	56245-67-1
Molecular Formula	C25H31NO
Molecular Weight	361.52 g/mol
Synonyms	(+)-Butaclamol; Dexbutaclamol; (3aS,4R,4aR,5aS,6R,10bS,12aS)-4a,5,5a,6,7,8,9,10,10b,11,12,12a-Dodecahydro-4H-3a,6-(epiminoethano)naphth[2,1-g]quinolin-4-ol; NSC 339024; Butaclamol, (+)-; Dexbutaclamol Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our (+)-Butaclamol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for advanced research chemicals and API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.