Description

Ethyl2,2-Difluoro-2-(3,4-Dichlorophenyl)Acetate is a high-purity fluorinated and chlorinated aromatic ester building block, serving as a critical intermediate in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroacetate moiety adjacent to a dichlorinated phenyl ring, enabling precise molecular construction. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms contribute to bioavailability and environmental stability.
• Material Science Research: Used in the synthesis of specialty monomers for advanced polymers with specific optical or electronic properties.
• Ligand and Catalyst Development: Serves as a precursor for creating complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring fluorinated aromatic compounds.

Basic Information

Product Name	Ethyl2,2-Difluoro-2-(3,4-Dichlorophenyl)Acetate
CAS No.	56177-76-5
Molecular Formula	C10H8Cl2F2O2
Molecular Weight	277.07 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3,4-dichlorophenyl)acetate; 2,2-Difluoro-2-(3,4-dichlorophenyl)acetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(3,4-dichlorophenyl)-, ethyl ester; Ethyl α,α-Difluoro-3,4-dichlorophenylacetate; 3,4-Dichloro-α,α-difluorophenylacetic Acid Ethyl Ester; (3,4-Dichlorophenyl)difluoroacetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl2,2-Difluoro-2-(3,4-Dichlorophenyl)Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.