Description

8-Chloro-10-[3-[4-(2-Hydroxyethyl)-1-Piperazinyl]Propyl]-10H-Phenothiazin-3-Ol Dihydrochloride is a high-purity, synthetically derived phenothiazine derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a critical pharmaceutical intermediate or reference standard for the synthesis and analytical characterization of complex active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of complex drug molecules, particularly within the phenothiazine therapeutic class.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) testing of APIs and finished drug products via techniques like HPLC and LC-MS.
• Biochemical Research: Employed in preclinical studies to investigate structure-activity relationships (SAR) and pharmacological properties of new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Functions as a direct precursor in the final stages of manufacturing specific, potent APIs for clinical use.
• Process Development & Scale-Up: Utilized by process chemists to optimize synthetic routes for efficient and cost-effective commercial-scale production.

Basic Information

Item	Details
Product Name	8-Chloro-10-[3-[4-(2-Hydroxyethyl)-1-Piperazinyl]Propyl]-10H-Phenothiazin-3-Ol Dihydrochloride
CAS No.	56158-51-1
Molecular Formula	C21H27ClN3O2S · 2HCl
Molecular Weight	503.90 g/mol (Free base: 420.98 g/mol)
Synonyms	8-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-10H-phenothiazin-3-ol dihydrochloride; Perphenazine Impurity; Perphenazine Related Compound; 1-[3-(8-Chloro-3-hydroxy-10H-phenothiazin-10-yl)propyl]-4-(2-hydroxyethyl)piperazine dihydrochloride; Phenothiazine derivative; 56158-51-1; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Chloro-10-[3-[4-(2-Hydroxyethyl)-1-Piperazinyl]Propyl]-10H-Phenothiazin-3-Ol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical-grade intermediates. Comprehensive Certificates of Analysis (COA) detailing purity (HPLC), related substances, and other critical parameters are provided with every shipment to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.