Description

(24R)-1(Alpha),24,25-Trihydroxyvitamin D3* is a high-purity, biologically active metabolite of vitamin D3, identified by CAS NO 56142-94-0. This compound is critical for research and development in endocrinology and metabolic regulation due to its role in calcium homeostasis and cellular differentiation. It is primarily utilized by pharmaceutical R&D teams, advanced research institutions, and manufacturers of high-grade reference standards for analytical and clinical studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and assay validation of vitamin D analogs and related pharmaceutical products.
• Biochemical Research: Used as a key reagent in studies investigating vitamin D receptor (VDR) signaling pathways, gene expression, and the molecular mechanisms of calcium and phosphate metabolism.
• Metabolite Analysis: Essential for developing and calibrating analytical methods (e.g., LC-MS/MS, HPLC) for the precise quantification of vitamin D metabolites in biological samples.
• Drug Discovery & Development: Acts as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis and development of novel therapeutics targeting bone disorders, psoriasis, and certain cancers.
• Cell Culture & In Vitro Studies: Employed in cell-based assays to study its effects on cell proliferation, differentiation, and immune function.

Basic Information

Product Name	(24R)-1(Alpha),24,25-Trihydroxyvitamin D3*
CAS No.	56142-94-0
Molecular Formula	C₂₇H₄₄O₄
Molecular Weight	432.64 g/mol
Synonyms	1α,24R,25-Trihydroxyvitamin D3; 1α,24R,25-Trihydroxycholecalciferol; (24R)-1α,24,25-Trihydroxyvitamin D3; 1α,24R,25-Trihydroxyvitamin D₃; (24R)-1α,24,25-Trihydroxycholecalciferol; 1α,24R,25-(OH)₃D₃; 24R-Hydroxy-1α,25-dihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our (24R)-1(Alpha),24,25-Trihydroxyvitamin D3* is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.