Description

Ionomycin Calcium Salt is a highly potent and selective calcium ionophore widely used in biochemical and pharmacological research. Its primary value lies in its ability to transport calcium ions across cellular membranes, making it an indispensable tool for studying calcium signaling pathways and cellular activation. This compound is essential for researchers in immunology, cell biology, and neuroscience, as well as for pharmaceutical development targeting calcium-dependent processes.

Application

• Intracellular Calcium Mobilization Studies: Used to artificially raise cytosolic calcium levels to study downstream signaling events, gene expression, and enzyme activation.
• Immunological Research: Employed as a co-stimulant with phorbol esters (e.g., PMA) to activate T-cells, B-cells, and other immune cells for functional assays and cytokine production studies.
• Cell Biology & Apoptosis Research: Facilitates the study of calcium's role in programmed cell death, mitochondrial function, and cell cycle progression.
• Neuroscience & Neurotransmitter Release: Used to investigate calcium-triggered exocytosis and the release of neurotransmitters from synaptic vesicles.
• Pharmaceutical Screening: Serves as a reference compound and tool in high-throughput screening for drugs that modulate calcium channels or intracellular calcium homeostasis.
• Stem Cell Differentiation: Applied in protocols to manipulate calcium signaling pathways that influence stem cell fate and differentiation.

Basic Information

Product Name	Ionomycin Calcium Salt
CAS No.	56092-82-1
Molecular Formula	C41H70CaO9
Molecular Weight	747.1 g/mol
Synonyms	Ionomycin, Calcium Salt; SQ 23377; Antibiotic SQ 23377; Ionomycin Ca2+ Salt; 6-{[(2S,3R,4S,5S,6R)-5-{[(2R,3S,4S,5S,6S)-4,5-Dihydroxy-6-methyl-3-{[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-methyloxan-2-yl]oxy}-4-{2-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-{[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]ethyl}-3,5-dihydroxy-2-methylhexanoic acid calcium salt
EINECS	Contact for details

Quality Control

Our Ionomycin Calcium Salt is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications to support your research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Tested for calcium ionophore activity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.