Description

Ionomycin is a potent, highly selective calcium ionophore widely used in biochemical and pharmacological research. Its core value lies in its ability to transport calcium ions across cell membranes with high specificity, making it an indispensable tool for studying calcium-mediated signaling pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for applications in immunology, cell biology, and drug discovery.

Application

• Intracellular Calcium Mobilization: A primary research tool for elevating cytosolic calcium concentrations to study calcium-dependent cellular processes.
• Immunology Research: Used to activate T-cells and other immune cells by mimicking antigen-receptor signaling, often in combination with phorbol esters.
• Apoptosis Studies: Employed to induce programmed cell death in various cell lines to investigate apoptotic pathways and screen for potential therapeutic agents.
• Cell Signaling & Transfection: Facilitates the study of signal transduction and can be used as a co-reagent in certain transfection protocols to enhance DNA uptake.
• Enzyme Activation: Activates calcium-dependent enzymes such as calpain, protein kinase C, and nitric oxide synthase for functional assays.
• Ion Channel Research: Serves as a positive control in assays designed to study the function and modulation of calcium channels and transporters.

Basic Information

Product Name	Ionomycin
CAS No.	56092-81-0
Molecular Formula	C41H72O9
Molecular Weight	709.0 g/mol
Synonyms	Ionomycin calcium salt; SQ 23377; Antibiotic SQ 23377; Ionomycin, Free Acid; Ionomycin from Streptomyces conglobatus; Calcimycin analog; Calcium Ionophore Ionomycin
EINECS	Contact for details

Quality Control

Our Ionomycin is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.