Description

Methyl 2,2-Difluoro-2-Phenylacetate is a versatile fluorinated building block essential for introducing the difluorophenylacetyl moiety into target molecules. This compound matters for its role in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where the difluoro group can significantly alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a difluorinated aromatic ester group.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorination enhances efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with unique properties.
• Fluorine Chemistry Research: A valuable standard and starting material for academic and industrial research into new fluorination methodologies and reaction mechanisms.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value fluorinated fine chemicals and flavors/fragrances.

Basic Information

Product Name	Methyl 2,2-Difluoro-2-Phenylacetate
CAS No.	56071-96-6
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2,2-Difluoro-2-phenylacetic acid methyl ester; Methyl α,α-difluorophenylacetate; Methyl difluorophenylacetate; α,α-Difluorophenylacetic acid methyl ester; Phenyl(difluoro)acetic acid methyl ester; Methyl (difluorophenyl)acetate; Methyl 2,2-difluoro-2-phenylethanoate; Difluorophenylacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluoro-2-Phenylacetate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.