Description

6-Maleimidocaproic Acid is a heterobifunctional crosslinking agent featuring a maleimide group and a carboxylic acid group separated by a six-carbon spacer. This compound is essential for creating stable, site-specific conjugates between thiol-containing molecules and amine-containing molecules under mild conditions. It is a critical intermediate for researchers and manufacturers in the bioconjugation, pharmaceutical development, and diagnostic reagent sectors, particularly for antibody-drug conjugate (ADC) synthesis and protein labeling.

Application

• Bioconjugation Reagent: A key building block for synthesizing heterobifunctional crosslinkers (e.g., SMCC, LC-SMCC) used to link proteins, peptides, and antibodies.
• Antibody-Drug Conjugate (ADC) Development: Serves as a fundamental linker component for attaching cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Protein and Peptide Modification: Used for site-specific labeling of thiol groups on biomolecules with fluorescent dyes, enzymes, or other probes for diagnostics and research.
• Surface Functionalization: Employed to modify surfaces (e.g., biosensor chips, nanoparticles) with maleimide groups for the immobilization of thiolated biomolecules.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating smart polymers and hydrogels with reactive handles for further bioconjugation.
• Diagnostic Assay Development: Utilized in the manufacture of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays for creating stable detection complexes.

Basic Information

Product Name	6-Maleimidocaproic Acid
CAS No.	55750-53-3
Molecular Formula	C10H13NO4
Molecular Weight	211.21 g/mol
Synonyms	6-Maleimidocaproic Acid; 6-(Maleimido)hexanoic Acid; Maleimidocaproic Acid; N-(5-Carboxypentyl)maleimide; 1-(5-Carboxypentyl)-1H-pyrrole-2,5-dione; EMCS (6-Maleimidocaproyloxy)succinimide ester precursor; CAS 55750-53-3
EINECS	Contact for details

Quality Control

Our 6-Maleimidocaproic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring the material meets the stringent specifications required for sensitive bioconjugation and pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and under inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.