Description

(R,R)-Dipamp is a highly valuable chiral bisphosphine ligand, widely recognized for its exceptional enantioselectivity in asymmetric hydrogenation and other catalytic transformations. Its primary commercial significance lies in enabling the efficient production of single-enantiomer intermediates for pharmaceuticals and fine chemicals, which is critical for meeting stringent regulatory and efficacy standards. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts to develop chiral APIs and specialty compounds.

Application

• As a privileged ligand for asymmetric hydrogenation catalysts, particularly for synthesizing enantiomerically pure amino acids and their derivatives.
• Key chiral auxiliary in the production of active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and anti-infective drugs.
• Catalyst component in the synthesis of chiral agrochemicals and flavors & fragrances.
• Used in academic and industrial research for developing new asymmetric synthetic methodologies.
• Employed in the manufacture of chiral ligands and metal complexes for homogeneous catalysis.
• Critical for process chemistry in scaling up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(R,R)-Dipamp
CAS No.	55739-58-7
Molecular Formula	C34H32P2
Molecular Weight	502.56 g/mol
Synonyms	(R,R)-1,2-Bis[(2-methoxyphenyl)phenylphosphino]ethane; (R,R)-DIPAMP; (-)-1,2-Bis[(2-methoxyphenyl)phenylphosphino]ethane; (R,R)-Bis[(2-methoxyphenyl)phenylphosphino]ethane; (R,R)-Ethane-1,2-diylbis[(2-methoxyphenyl)phenylphosphane]; DIPAMP ligand; (R,R)-DIPAMP ligand; (2R,3R)-Bis(diphenylphosphino)butane (common misnomer, correct structure is with methoxyphenyl groups)
EINECS	Contact for details

Quality Control

Our (R,R)-Dipamp is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and elemental analysis. A Certificate of Analysis (COA) detailing purity, chiral purity, and residual solvent levels is provided with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain optimal catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.