Description

Insulin, Despentapeptide(B26-B30)- CAS NO 55599-09-2 is a synthetic insulin analog, specifically a truncated form of human insulin where the last five amino acids of the B-chain (positions 26-30) have been removed. This modification is of significant interest in pharmaceutical research for studying insulin's structure-activity relationships and developing novel therapeutic analogs with altered pharmacokinetic profiles. It serves as a critical intermediate and reference standard for researchers and manufacturers in the biopharmaceutical sector focused on diabetes treatment and metabolic disorder research.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis and study of novel, fast-acting insulin analogs.
• Reference Standard: For analytical method development, validation, and quality control in insulin and peptide hormone production.
• Biochemical Studies: To investigate the role of the C-terminal region of the insulin B-chain in receptor binding and biological activity.
• Metabolic Disorder Research: Used in preclinical studies to understand insulin signaling and explore new therapeutic avenues for diabetes.
• Academic Research: A valuable tool in university and institutional labs for teaching and advanced research in peptide chemistry and endocrinology.

Basic Information

Item	Detail
Product Name	Insulin, Despentapeptide(B26-B30)- CAS NO 55599-09-2
CAS No.	55599-09-2
Molecular Formula	C249H381N65O76S6
Molecular Weight	~5708.5 g/mol
Synonyms	Des(B26-B30)-Insulin; Insulin (human), Despentapeptide(B26-B30)-; [Des-pentapeptide(B26-B30)]-insulin; Human Insulin Des-Pentapeptide (B26-B30); Insulin B-Chain (1-25)-peptide; Truncated Insulin Analog; Insulin B(1-25)-A(1-21) Disulfide; Insulin Intermediate
EINECS	Contact for details

Quality Control

Our Insulin, Despentapeptide(B26-B30)- is produced under strict quality management systems. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity and identity, mass spectrometry (MS) for molecular weight confirmation, and tests for related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (Karl Fischer)	≤ 5.0%
Peptide Content (UV)	≥ 80%
Biological Activity	Assessed per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.