Description

5-(4-Trifluoromethylphenyl)-Furan-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block, prized for its unique structural motif that combines a furan ring with a trifluoromethylphenyl group. This compound is essential for introducing lipophilicity, metabolic stability, and specific electronic properties into advanced molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for targets in oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its conjugated system and fluorine content.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag to study protein-ligand interactions and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic structures.

Basic Information

Product Name	5-(4-Trifluoromethylphenyl)-Furan-2-Carboxylic Acid
CAS No.	55377-78-1
Molecular Formula	C12H7F3O3
Molecular Weight	256.18 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]-2-furancarboxylic acid; 2-Furoic acid, 5-[4-(trifluoromethyl)phenyl]-; 5-(4-Trifluoromethylphenyl)furan-2-carboxylic acid; 5-(p-Trifluoromethylphenyl)-2-furoic acid; 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carboxylic acid (related); Furan-2-carboxylic acid, 5-(4-trifluoromethylphenyl)-; TFPFA
EINECS	Contact for details

Quality Control

Our production of 5-(4-Trifluoromethylphenyl)-Furan-2-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.