Description

Arylsulfatase B is a crucial lysosomal enzyme that catalyzes the hydrolysis of sulfate esters from glycosaminoglycans. This enzymatic activity is essential for cellular metabolism and the breakdown of complex biological molecules. It is primarily utilized in life science research, diagnostic assay development, and as a critical reagent in biochemical studies related to lysosomal storage disorders. The product is supplied as Arylsulfatase B CAS NO 55354-43-3.

Application

• Biochemical Research: Used as a model enzyme to study lysosomal function, enzyme kinetics, and sulfate metabolism pathways.
• Diagnostic Reagent Manufacturing: A key component in the production of in-vitro diagnostic (IVD) kits for detecting enzyme deficiencies, such as in Maroteaux-Lamy syndrome (MPS VI).
• Pharmaceutical Development: Employed in activity assays for drug discovery programs targeting lysosomal storage diseases and for quality control of enzyme replacement therapies.
• Substrate Specificity Studies: Used to investigate and characterize the hydrolysis of specific sulfated substrates in metabolic pathways.
• Cell Culture & Biotechnology: Applied in specialized cell culture media and bioprocessing for studying cellular degradation mechanisms.
• Reference Standard: Serves as a purified standard for calibrating laboratory equipment and validating analytical methods in clinical and research laboratories.

Basic Information

Product Name	Arylsulfatase B
CAS No.	55354-43-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetylgalactosamine-4-sulfatase; ASB; Chondroitinsulfatase; Galactose-6-sulfate sulfatase; ARSB; Arylsulfatase B (human); Maroteaux-Lamy syndrome protein; EC 3.1.6.12
EINECS	Contact for details

Quality Control

Our Arylsulfatase B is produced and tested under stringent quality management systems. Each lot undergoes comprehensive analysis to ensure high purity, specific activity, and functional integrity. Certificates of Analysis (COA) detailing purity, activity units, and absence of significant contaminants are provided to guarantee reliable performance in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions. Keep container tightly sealed when not in use to maintain stability and prevent loss of activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	≥ [Value] %
Purity (SDS-PAGE)	≥ [Value] %
pH (in solution)	6.0 - 7.5
Endotoxin (LAL)	< [Value] EU/mg
Residual Moisture (KF)	< [Value] %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.