Description

3-[(2S)-1-Lithiopiperidin-2α-Yl]Pyridine is a specialized organolithium reagent featuring a chiral piperidine scaffold. This compound matters as a highly reactive intermediate for introducing stereochemical complexity in advanced synthetic pathways, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value chiral molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, especially in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used as a chiral nucleophile or base in stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Ligand Precursor: Serves as a precursor for the development of novel chiral ligands used in catalysis.
• Academic & Industrial R&D: Essential reagent for methodological development and exploring new synthetic routes in organic chemistry laboratories.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules during process development phases.

Basic Information

Item	Detail
Product Name	3-[(2S)-1-Lithiopiperidin-2α-Yl]Pyridine
CAS No.	55345-40-9
Molecular Formula	C10H13LiN2
Molecular Weight	156.16 g/mol
Synonyms	(2S)-1-Lithio-2-(3-pyridyl)piperidine; 2-(3-Pyridinyl)-1-lithiopiperidine, (2S)-; 3-[(2S)-1-Lithio-2-piperidinyl]pyridine; 3-((S)-1-Lithiopiperidin-2-yl)pyridine; (S)-1-Lithio-2-(pyridin-3-yl)piperidine; Lithiated (S)-2-(3-Pyridyl)piperidine; Chiral lithium amide of 3-(2-Piperidinyl)pyridine
EINECS	Contact for details

Quality Control

Our production of 3-[(2S)-1-Lithiopiperidin-2α-Yl]Pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials are characterized by appropriate analytical techniques, including NMR and titration, to confirm identity, purity, and reactivity. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere), hygroscopic (moisture-sensitive), and highly volatile, this reagent must be stored under a dry, inert atmosphere (argon or nitrogen) at recommended cold temperatures, typically between 2°C and 8°C. Handle and aliquot only under an inert atmosphere using standard Schlenk or glovebox techniques to maintain purity and reactivity.

Specification

Item	Specification
Appearance	Solution (color may vary)
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 0.5 M in specified solvent
Solvent	Typically Tetrahydrofuran or Diethyl Ether
Chiral Purity (Chiral HPLC)	≥ 98% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.