Description

n-Boc-N'-(9-Xanthenyl)-L-Glutamine is a protected amino acid derivative widely used as a key synthetic intermediate in organic and peptide chemistry. Its value lies in the orthogonal protection strategy it offers, where the Boc (tert-butoxycarbonyl) group safeguards the amine and the Xanthyl (Xan) group protects the side-chain amide, enabling precise, sequential deprotection for complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics, diagnostic agents, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: Critical building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics with glutamine residues.
• Protecting Group Strategy: Enables selective deprotection sequences in multi-step organic syntheses, crucial for constructing sophisticated molecular architectures.
• Bioconjugation: Used in the preparation of labeled peptides and protein conjugates for research and diagnostic applications.
• Medicinal Chemistry Research: Serves as a precursor in the discovery and optimization of new drug candidates targeting various diseases.
• Chemical Biology Probes: Facilitates the synthesis of activity-based probes and other tools for studying enzyme function and protein-protein interactions.
• Custom Peptide Synthesis: A vital reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide services.

Basic Information

Product Name	n-Boc-N'-(9-Xanthenyl)-L-Glutamine
CAS No.	55260-24-7
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-γ-(9-xanthenyl)-L-glutamine; Boc-Gln(Xan)-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-5-(9H-xanthen-9-ylamino)-5-oxopentanoic acid; N-(tert-Butoxycarbonyl)-N'-(9-xanthenyl)-L-glutamine; L-Glutamine, N-[(1,1-dimethylethoxy)carbonyl]-N'-(9H-xanthen-9-yl)-; Boc-L-Glutamine(Xan); tert-Butyl N-[(1S)-4-(9H-xanthen-9-ylamino)-1-(carboxymethyl)-4-oxobutyl]carbamate
EINECS	Contact for details

Quality Control

Every batch of n-Boc-N'-(9-Xanthenyl)-L-Glutamine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity specifications suitable for research and development applications. Certificates of Analysis (COA) detailing purity (HPLC), chiral purity, and other critical parameters are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.