Description

Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester is a protected derivative of the essential amino acid L-Histidine, featuring a trifluoroacetyl group on the α-amino function and a butyl ester on the carboxyl group. This specific protection scheme is crucial for enabling selective peptide synthesis and advanced organic transformations where standard protecting groups are insufficient. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: Serves as a key protected building block in solid-phase and solution-phase peptide synthesis, particularly for introducing histidine residues.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation Chemistry: Acts as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Research: Employed in studying protein-protein interactions and enzyme mechanisms by incorporating modified histidine analogs.
• Process Development: Used in scaling up synthetic routes for complex peptides under GMP or non-GMP conditions.
• Reference Standard: Functions as a high-purity analytical standard for quality control in peptide manufacturing.

Basic Information

Product Name	Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester
CAS No.	55255-83-9
Molecular Formula	C14H20F3N3O3
Molecular Weight	335.32 g/mol
Synonyms	L-Histidine, N2-[(trifluoroacetyl)-, butyl ester; Butyl Nα-(trifluoroacetyl)-L-histidinate; Nα-TFA-L-Histidine Butyl Ester; (S)-2-(Trifluoroacetamido)-3-(1H-imidazol-4-yl)propanoic acid butyl ester; TFA-His-Obzl; N-α-Trifluoroacetyl-L-histidine butyl ester; Fmoc-His(Trt)-OH related intermediate; Protected L-Histidine butyl ester
EINECS	Contact for details

Quality Control

Our Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.