Description

1,25-Dihydroxyergocalciferol is the active metabolite of vitamin D2, also known as ercalcitriol. This compound is a critical regulator of calcium and phosphate metabolism, making it essential for bone health and cellular function. It is primarily utilized in advanced pharmaceutical research and development, particularly for studying calcium-related disorders and developing targeted therapies. Key industries requiring this high-purity biochemical include pharmaceutical manufacturing, biotechnology research, and reference standard production.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key intermediate or active component in the development of prescription medications for treating conditions like hypocalcemia, osteoporosis, and renal osteodystrophy.
• Biochemical Research: Used as a critical tool in life science laboratories to study vitamin D receptor (VDR) signaling pathways, gene expression, and cellular differentiation.
• Reference Standard: Employed as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality control and assay validation in pharmaceutical and nutraceutical industries.
• Nutraceutical Development: Investigated for use in advanced dietary supplements targeting bone and immune system support, though final formulations require strict regulatory compliance.
• Cell Culture & In Vitro Studies: Applied in media supplements to study the effects of vitamin D metabolites on various cell lines, including those related to bone, kidney, and immune function.

Basic Information

Product Name	1,25-Dihydroxyergocalciferol
CAS No.	55248-15-2
Molecular Formula	C28H44O3
Molecular Weight	428.65 g/mol
Synonyms	Ercalcitriol; 1,25-Dihydroxyvitamin D2; 1α,25-Dihydroxyergocalciferol; (5Z,7E,22E)-(1S,3R,24R)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,24-triol; 1α,25-Dihydroxyvitamin D2; 1,25(OH)2D2; Vitamin D2 Hormone
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxyergocalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR). We provide Certificates of Analysis (COA) with each shipment, detailing all critical parameters. While not intended as a USP/NF grade unless specified, our standard material meets the stringent requirements for research and development applications, ensuring reliable and reproducible results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to minimize moisture exposure. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.