Description

6-Hydroxy-8-Demethylzolazepam is a key benzodiazepine derivative and an important intermediate in pharmaceutical research and development. This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs) and reference standards for analytical purposes. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and fine chemical manufacturers focused on neuropharmacology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control testing in pharmaceutical analysis.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for related therapeutic compounds.
• Medicinal Chemistry Research: Serves as a core scaffold for the design and development of new chemical entities targeting the central nervous system.
• Impurity Standard: Utilized to identify, quantify, and control related substance impurities in final drug products.

Basic Information

Product Name	6-Hydroxy-8-Demethylzolazepam
CAS No.	55199-56-9
Molecular Formula	C15H12FN3O2
Molecular Weight	285.27 g/mol
Synonyms	8-Desmethyl-6-hydroxyzolazepam; 6-Hydroxy-8-desmethylzolazepam; 6-Hydroxy-8-demethyl tiletamine impurity; Zolazepam metabolite; 4H-Imidazo[1,5-a][1,4]benzodiazepin-6-ol, 8-fluoro-5-methyl-1-(1-methylethyl)-; Telazol metabolite intermediate
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-8-Demethylzolazepam is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider desiccants or an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.