Description

Secretin, Tyr(6)- is a synthetic analogue of the gastrointestinal peptide hormone secretin, specifically modified with a tyrosine residue at position 6. This modification can enhance stability or alter receptor binding affinity, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers investigating gastrointestinal physiology, hormone-receptor interactions, and peptide-based therapeutics.

Application

• Biomedical Research: Used as a specific agonist or probe to study the secretin receptor (SCTR) signaling pathways and its role in pancreatic bicarbonate secretion and gastric acid inhibition.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the development of novel therapeutics for gastrointestinal disorders, such as pancreatitis or gastrinoma.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to measure secretin levels in clinical or research samples.
• Physiological Studies: Applied in in vitro and in vivo models to investigate the hormonal regulation of digestive functions and water-electrolyte homeostasis.
• Peptide Chemistry & Conjugation: Acts as a substrate for further chemical modification, labeling (e.g., with fluorophores or radioisotopes), or conjugation due to the presence of the tyrosine residue.

Basic Information

Product Name	Secretin, Tyr(6)-
CAS No.	55197-91-6
Molecular Formula	C134H220N44O41
Molecular Weight	3055.4 g/mol
Synonyms	Tyr6-Secretin; Secretin (Tyr(6)-); [Tyr6]-Secretin; Secretin, 6-L-tyrosine-; H-His-Ser-Asp-Gly-Thr-Phe-Tyr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2; SCT, Tyr6-; Gastrointestinal peptide hormone analogue
EINECS	Contact for details

Quality Control

Our Secretin, Tyr(6)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and endotoxins where applicable. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.