Description

1-Methyl-Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester is a protected derivative of the amino acid L-histidine, featuring a trifluoroacetyl group on the α-amine and a butyl ester on the carboxylate. This compound is a critical building block (synthon) in advanced organic synthesis, particularly for the preparation of complex peptides and peptidomimetics where the histidine side chain requires specific protection strategies. It is primarily utilized by pharmaceutical research and development teams, as well as by fine chemical manufacturers engaged in producing active pharmaceutical ingredients (APIs) and biochemical tools.

Application

• Peptide Synthesis: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for incorporating modified histidine residues.
• Pharmaceutical Research: Used in the research and development of novel peptide-based therapeutics, including enzyme inhibitors and receptor ligands.
• Bioconjugation: Acts as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology: Employed in the synthesis of custom peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Development: Utilized in scaling up the production of target peptides for preclinical and clinical studies.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	1-Methyl-Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester
CAS No.	55145-65-8
Molecular Formula	C13H18F3N3O3
Molecular Weight	321.30 g/mol
Synonyms	N(alpha)-(Trifluoroacetyl)-1-methyl-L-histidine butyl ester; 1-Methyl-N(alpha)-trifluoroacetyl-L-histidine butyl ester; L-Histidine, N2-[(trifluoroacetyl)-1-methyl-, butyl ester; Butyl 1-methyl-Nα-(trifluoroacetyl)-L-histidinate; Nα-TFA-1-Me-L-His-OBu; Fmoc-His(1-Me, Nα-TFA)-OH butyl ester derivative (precursor); Protected 1-Methylhistidine butyl ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-Nα-(Trifluoroacetyl)-L-Histidine Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the stringent requirements of research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly. Keep container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.