Description

Succinylconcanavalin A CAS NO 55128-23-9 is a chemically modified derivative of the plant lectin concanavalin A, where succinic anhydride is used to acylate lysine residues. This modification is critical as it reduces the protein's native tetrameric structure to a dimeric form, significantly altering its carbohydrate-binding properties and specificity. This engineered lectin is an essential tool for researchers and developers in the life sciences, particularly for advanced glycobiology studies, biosensor development, and affinity chromatography applications. Its tailored binding profile makes it invaluable for isolating and characterizing complex glycoproteins and glycolipids.

Application

• Glycobiology Research: Used as a specific probe to study carbohydrate-protein interactions, cell surface glycosylation patterns, and lectin-mediated signaling pathways.
• Affinity Chromatography: Serves as a stationary phase ligand for the purification and isolation of specific glycoproteins, polysaccharides, and glycol-conjugates from complex biological mixtures.
• Diagnostic Assay Development: Employed in the design of biosensors, microarray platforms, and ELISA-based kits for detecting specific carbohydrate antigens or biomarkers.
• Cell Separation and Analysis: Utilized in flow cytometry (FACS) and magnetic-activated cell sorting (MACS) to isolate cell populations based on distinct surface glycan profiles.
• Drug Delivery & Targeting: Investigated for its potential in targeted therapeutic systems due to its specific binding to certain cell surface glycans.
• Quality Control in Biopharma: Applied in the analysis of glycosylation patterns of therapeutic proteins, such as monoclonal antibodies, to ensure batch consistency and efficacy.

Basic Information

Product Name	Succinylconcanavalin A
CAS No.	55128-23-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Succinyl-Con A; Suc-Con A; Concanavalin A, succinylated; Succinylated concanavalin A; Modified concanavalin A; Lectin from Canavalia ensiformis (Jack bean), succinylated; Affinity chromatography lectin, succinyl derivative; Dimetic concanavalin A
EINECS	Contact for details

Quality Control

Our Succinylconcanavalin A is produced under stringent conditions to ensure high biological activity and lot-to-lot consistency, suitable for research and diagnostic applications. Each batch undergoes rigorous quality testing, including assessment of protein concentration, carbohydrate-binding activity, and purity analysis via electrophoresis and chromatography. A comprehensive Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee compliance with your experimental requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storing at -20°C in aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to structure
Protein Content (Biuret)	≥ 90%
Activity (Hemagglutination)	Specific activity provided per batch
Purity (SDS-PAGE)	Major band ≥ 85%
Solubility	Soluble in water and buffer solutions
pH (1% solution)	6.0 - 8.0
Endotoxin (LAL)	< 1.0 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.