Description

Colipase is a crucial cofactor protein that activates pancreatic lipase, the primary enzyme responsible for dietary fat digestion. Its presence is essential for the efficient hydrolysis of triglycerides into absorbable fatty acids and monoglycerides in the intestinal lumen. This biochemical role makes high-purity Colipase CAS NO 55126-92-6 a vital reagent for research in gastroenterology, enzymology, and the development of diagnostic assays and therapeutic agents for pancreatic insufficiency.

Application

• Biochemical Research: Used as a critical cofactor in in vitro studies of pancreatic lipase kinetics, mechanism, and inhibition.
• Diagnostic Kit Manufacturing: A key component in enzymatic assay kits designed to measure pancreatic function and lipase activity in clinical samples.
• Pharmaceutical Development: Employed in research for developing enzyme replacement therapies and formulations for conditions like cystic fibrosis and chronic pancreatitis.
• Nutritional Science Studies: Utilized in model systems to investigate fat digestion, absorption, and the impact of various food matrices on lipolytic activity.
• Enzyme Purification & Characterization: Acts as a stabilizing agent and activity enhancer during the purification and functional analysis of lipases from various sources.

Basic Information

Product Name	Colipase
CAS No.	55126-92-6
Molecular Formula	C254H402N74O75S6 (for porcine colipase, typical)
Molecular Weight	~10 kDa (Approximate, varies by source and isoform)
Synonyms	CLPS; Colipase I; Pancreatic Colipase; Colipase A; Colipase B; Co-lipase; Lipase Cofactor; Lipase-Stimulating Protein
EINECS	Contact for details

Quality Control

Our Colipase is produced and tested under stringent quality management systems. Each batch is characterized for identity, purity, and functional activity to ensure consistency and reliability for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing specifications such as protein content, activity units/mg, and purity by HPLC/SDS-PAGE is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR/HPLC)	Conforms to reference standard
Protein Content (Biuret)	> 90%
Purity (SDS-PAGE)	> 95%
Specific Activity	> 10,000 U/mg protein (Contact for batch-specific data)
Solubility	Soluble in water or buffer
Endotoxin	< 1.0 EU/μg (for research-grade)
Loss on Drying	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.