Description

n-(Trifluoroacetyl)-D-Norvaline 1-Methylpropyl Ester is a high-purity, chiral building block and protected amino acid derivative. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected D-norvaline derivative.
• Chemical Biology Research: Employed in the study of enzyme-substrate interactions and the development of bioactive probes.
• Asymmetric Synthesis: Serves as a starting material or intermediate for the preparation of other non-natural amino acids and chiral compounds.
• Agrochemical Research: Potential use in the synthesis of chiral active ingredients for crop protection products.

Basic Information

Product Name	n-(Trifluoroacetyl)-D-Norvaline 1-Methylpropyl Ester
CAS No.	54889-86-0
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	D-Norvaline, N-(trifluoroacetyl)-, 1-methylpropyl ester; (R)-2-((2,2,2-Trifluoroacetyl)amino)pentanoic acid sec-butyl ester; N-(Trifluoroacetyl)-D-norvaline sec-butyl ester; D-Norvaline-N-TFA sec-butyl ester; 54889-86-0; (R)-sec-Butyl 2-(2,2,2-trifluoroacetamido)pentanoate
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-D-Norvaline 1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.