Description

n-(Trifluoroacetyl)-L-Norvaline Butyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules in pharmaceutical and biochemical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and peptide synthesis industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in peptide-mimetic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected norvaline derivative, where the trifluoroacetyl (TFA) group acts as an amine-protecting group.
• Agrochemical Research: Serves as a building block for creating chiral compounds with potential herbicidal or insecticidal activity.
• Biochemical Probe Development: Utilized in the design and synthesis of enzyme inhibitors, receptor ligands, and other molecular probes for biological studies.
• Fine Chemical Synthesis: Employed in asymmetric synthesis and other advanced organic transformations to introduce the L-norvaline moiety into target molecules.
• Material Science: Potential precursor for specialty polymers or coatings requiring specific chiral centers or fluorine content.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Norvaline Butyl Ester
CAS No.	54889-85-9
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	L-Norvaline, N-(trifluoroacetyl)-, butyl ester; Butyl N-(trifluoroacetyl)-L-norvalinate; N-Trifluoroacetyl-L-norvaline butyl ester; (S)-2-(Trifluoroacetamido)pentanoic acid butyl ester; TFA-L-Norvaline-OBut; N-[(Trifluoroacetyl)-L-norvaline] butyl ester; Butyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]pentanoate
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Norvaline Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.