Description

Dapsone n-β-D-Glucuronide Sodium Salt is a high-purity, conjugated metabolite reference standard of the pharmaceutical agent dapsone. This compound is essential for advanced analytical and research applications requiring precise quantification and identification. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for method development, validation, and bioanalytical studies.

Application

• Pharmacokinetic and Metabolism Studies: Used as a certified reference standard to quantify dapsone glucuronide metabolites in biological matrices (plasma, urine) for ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Bioanalytical Method Development: Serves as a critical calibrant and quality control sample in HPLC, LC-MS, and LC-MS/MS assay development for therapeutic drug monitoring and regulatory submissions.
• Pharmaceutical Impurity Profiling: Employed to identify and quantify glucuronide conjugate impurities in active pharmaceutical ingredient (API) batches of dapsone and related compounds.
• Clinical Research: Acts as a key reagent in studies investigating individual metabolic variation, drug-drug interactions, and personalized medicine approaches for dapsone-based therapies.
• Forensic and Doping Control Analysis: Utilized as a reference material in confirmatory testing for the presence of dapsone and its metabolites.

Basic Information

Product Name	Dapsone n-β-D-Glucuronide Sodium Salt
CAS No.	54749-81-4
Molecular Formula	C18H19N2O8SNa
Molecular Weight	446.41 g/mol
Synonyms	Dapsone N-Glucuronide Sodium Salt; DDS N-Glucuronide Sodium Salt; 4,4'-Sulfonylbis(aniline) N-Glucuronide Sodium Salt; Dapsone β-D-Glucopyranosiduronic Acid Sodium Salt; Dapsone Glucuronide Sodium; Sodium Dapsone Glucuronide; Dapsone 1-O-β-Glucuronide Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Dapsone n-β-D-Glucuronide Sodium Salt is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.