Description

4-(2,2-Difluorocyclopropyl)-Toluene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluorocyclopropyl moiety, which is a key structural motif for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced pyrethroid-like insecticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of fluorinated polymers with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated aromatic cores for electronic display materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions to create complex, biaryl structures.
• Fluorine Chemistry Exploration: A valuable tool for academic and industrial researchers studying the effects of gem-difluorocyclopropane rings on aromatic system electronics and conformation.

Basic Information

Product Name	4-(2,2-Difluorocyclopropyl)-Toluene
CAS No.	54672-44-5
Molecular Formula	C10H10F2
Molecular Weight	168.18 g/mol
Synonyms	1-(2,2-Difluorocyclopropyl)-4-methylbenzene; p-(2,2-Difluorocyclopropyl)toluene; 4-Methyl-2',2'-difluorocyclopropylbenzene; Toluene, 4-(2,2-difluorocyclopropyl)-; α,α-Difluoro-2-(p-tolyl)cyclopropane
EINECS	Contact for details

Quality Control

Our 4-(2,2-Difluorocyclopropyl)-Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.