Description

Lithium (Trimethylsilyl)Acetylide is a highly reactive organolithium reagent, widely valued for its role as a versatile acetylene anion equivalent in organic synthesis. Its core value proposition lies in enabling efficient carbon-carbon bond formation, particularly for the synthesis of complex alkynes and advanced pharmaceutical intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing alkynyl moieties in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate acetylene functional groups.
• Material Science & Polymer Chemistry: Serves as a monomer or building block for creating specialized polymers, dendrimers, and conductive organic materials.
• Natural Product & Fine Chemical Synthesis: Facilitates the introduction of acetylene units into complex natural product analogs and high-value fine chemicals.
• Cross-Coupling Reactions: Acts as a nucleophile in Sonogashira and other palladium-catalyzed cross-coupling reactions to form disubstituted alkynes.
• Nucleophilic Addition to Carbonyls: Employed for the efficient addition to aldehydes, ketones, and other electrophiles to produce propargylic alcohols.

Basic Information

Product Name	Lithium (Trimethylsilyl)Acetylide
CAS No.	54655-07-1
Molecular Formula	C5H9LiSi
Molecular Weight	104.15 g/mol
Synonyms	Lithium(trimethylsilyl)ethynylide; (Trimethylsilyl)ethynyllithium; Lithium trimethylsilylacetylide; TMS-acetylene lithium salt; Ethynyltrimethylsilane, lithium derivative; Lithium (trimethylsilyl)ethynylide; Lithium TMS-acetylide
EINECS	Contact for details

Quality Control

Our Lithium (Trimethylsilyl)Acetylide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including titration for active reagent content and spectroscopic identification. A Certificate of Analysis (COA) detailing purity, assay, and solvent content is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Due to its high volatility and pyrophoric nature in solution, handle and store exclusively under inert conditions. Recommended long-term storage temperature is 2-8°C for solutions; consult the specific technical data sheet for solid form storage guidance.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (by Titration)	≥ 0.5 M in specified solvent (e.g., THF, Hexanes)
Purity (NMR)	≥ 95%
Water Content (Karl Fischer)	≤ 100 ppm
Solvent	As specified (Typical: Tetrahydrofuran, Hexane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.