Description

Lorazepam Related Compound D (25 Mg) (6-Chloro-4-(o-Chlorophenyl)-2-Quinazolinecar-Boxylic Acid) CAS NO 54643-79-7 is a high-purity analytical reference standard critical for pharmaceutical research and quality control. This compound serves as a key impurity marker and degradation product for the active pharmaceutical ingredient Lorazepam, ensuring the safety and efficacy of the final drug product. It is essential for analytical chemists and quality assurance professionals in pharmaceutical development and manufacturing who require reliable standards for method validation, stability studies, and regulatory compliance.

Application

• Pharmaceutical Impurity Profiling and Identification in Lorazepam API and finished dosage forms.
• Analytical Method Development and Validation for HPLC, UPLC, and GC assays.
• Stability-Indicating Studies to monitor degradation pathways of Lorazepam under various stress conditions.
• Quality Control (QC) and Quality Assurance (QA) testing in pharmaceutical manufacturing to meet ICH guidelines.
• Certified Reference Material (CRM) for calibrating laboratory equipment and ensuring analytical accuracy.
• Regulatory Submissions, providing essential data for FDA, EMA, and other global health authority filings.
• Research and Development into the metabolism and pharmacokinetics of benzodiazepine drugs.

Basic Information

Product Name	Lorazepam Related Compound D (25 Mg) (6-Chloro-4-(o-Chlorophenyl)-2-Quinazolinecar-Boxylic Acid)
CAS No.	54643-79-7
Molecular Formula	C16H10Cl2N2O2
Molecular Weight	333.17 g/mol
Synonyms	6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid; Lorazepam Impurity D; Lorazepam Related Substance D; 6-Chloro-4-(o-chlorophenyl)quinazoline-2-carboxylic acid; Ativan Related Compound D; Benzodiazepine Impurity D; 2-Quinazolinecarboxylic acid, 6-chloro-4-(2-chlorophenyl)-; UNII-9J4865IF6V
EINECS	Contact for details

Quality Control

Every batch of Lorazepam Related Compound D is manufactured and analyzed under strict quality systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced techniques like HPLC and NMR to ensure compliance with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, supporting your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.