Description

Boc-Hyp(Bzl)-Oh CAS NO 54631-81-1 is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-O-benzyl-L-hydroxyproline, widely used as a critical building block in peptide synthesis. This compound is essential for introducing the unique conformational properties of hydroxyproline into peptide chains, which is vital for modulating biological activity and stability. It is a key raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors developing peptide-based therapeutics, diagnostics, and biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the stepwise construction of complex peptides, particularly those requiring hydroxyproline residues.
• Pharmaceutical Intermediate: Used in the research and production of peptide drugs targeting collagen-related disorders, fibrosis, and other therapeutic areas.
• Bioconjugation & Labeling: Serves as a precursor for creating functionalized peptides for drug delivery systems, imaging probes, and diagnostic agents.
• Collagen Mimetic Peptides: Critical for synthesizing peptides that mimic the structure and function of natural collagen for tissue engineering and cosmetic applications.
• GPCR Ligand Development: Employed in the synthesis of peptide ligands for G-protein-coupled receptors (GPCRs), a major drug target class.
• Academic & Industrial R&D: A standard reagent in laboratories for exploring peptide structure-activity relationships and developing novel bioactive compounds.

Basic Information

Product Name	Boc-Hyp(Bzl)-Oh
CAS No.	54631-81-1
Molecular Formula	C₁₇H₂₃NO₅
Molecular Weight	321.37 g/mol
Synonyms	N-Boc-O-benzyl-L-hydroxyproline; (2S,4R)-1-(tert-Butoxycarbonyl)-4-(benzyloxy)pyrrolidine-2-carboxylic Acid; Boc-4-(Bzl)-Hyp-OH; Boc-Hyp(OBzl)-OH; tert-Butyl (4S)-4-(benzyloxy)-L-prolyl-(2S)-2-carboxylate; N-tert-Butoxycarbonyl-O-benzyl-trans-4-hydroxy-L-proline; Fmoc-Hyp(Bzl)-OH precursor
EINECS	Contact for details

Quality Control

Our Boc-Hyp(Bzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D = Specific value provided on COA
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.