Description

4-Hydroxyritalinic Acid is a key pharmaceutical intermediate and metabolite of methylphenidate. This compound is critical for analytical research, drug metabolism studies, and the development of new therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for quality control and bioanalytical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of methylphenidate metabolites in bioanalytical studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, bioavailability, and excretion profiles of stimulant medications.
• Impurity Profiling: Serves as a known impurity or degradation product standard in the quality control of active pharmaceutical ingredients (APIs) like methylphenidate hydrochloride.
• Forensic Analysis: Employed in toxicology laboratories for the accurate detection and confirmation of methylphenidate use in clinical and forensic samples.
• Academic & Clinical Research: Supports investigative studies on the pharmacological effects and long-term safety profiles of psychostimulant drugs.
• Method Development & Validation: A crucial component for developing and validating sensitive analytical methods such as HPLC, LC-MS/MS, and GC-MS.

Basic Information

Product Name	4-Hydroxyritalinic Acid
CAS No.	54593-32-7
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	4-Hydroxyritalinic Acid; α-Phenyl-2-piperidineacetic acid, 4-hydroxy-; 4-Hydroxy methylphenidate acid; ritalinic acid, 4-hydroxy-; 4-OH-Ritalinic Acid; 4-Hydroxy-α-phenyl-2-piperidineacetic acid; Methylphenidate metabolite 4; L-α-Phenyl-2-piperidineacetic acid, 4-hydroxy-
EINECS	Contact for details

Quality Control

Our 4-Hydroxyritalinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical reference standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.