Description

tert-Butyl 2-(Aminocarbonyl)Pyrrolidine-1-Carboxylate is a high-purity, protected pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring proline-like scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or functionalized molecules used in target identification and validation studies.
• Agrochemical Synthesis: Employed in the development of advanced crop protection agents that require specific stereochemistry.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 2-(Aminocarbonyl)Pyrrolidine-1-Carboxylate
CAS No.	54503-10-5
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	1-Boc-2-carbamoylpyrrolidine; N-Boc-L-Prolineamide; tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-pyrrolidinecarboxamide; 2-Carbamoyl-1-pyrrolidinecarboxylic acid tert-butyl ester; Boc-Proline amide; Boc-Pro-NH2; (S)-1-Boc-2-pyrrolidinecarboxamide
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Aminocarbonyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. We offer material suitable for research and development use, with typical purity levels exceeding 97% (by HPLC). Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be tailored to meet the stringent requirements of cGMP (current Good Manufacturing Practice) for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.