Description

3,5-Difluorothioanisole is a versatile fluorinated aromatic thioether building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms on the benzene ring, which allows for precise modulation of electronic properties and metabolic stability in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluorothioanisole moiety contributes to efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl and heterocyclic systems.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: An essential compound for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemical chemistry.

Basic Information

Product Name	3,5-Difluorothioanisole
CAS No.	54378-77-7
Molecular Formula	C7H6F2S
Molecular Weight	160.19 g/mol
Synonyms	1,3-Difluoro-5-(methylthio)benzene; 3,5-Difluorophenyl Methyl Sulfide; Methyl 3,5-Difluorophenyl Sulfide; (3,5-Difluorophenyl)(methyl)sulfane; 3,5-Difluorothioanisole; 54378-77-7; 3,5-Difluorophenyl methyl thioether
EINECS	Contact for details

Quality Control

Our 3,5-Difluorothioanisole is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.