Description

(6R-Cis)-3-(Hydroxymethyl)-7-Methoxy-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate, specifically a key β-lactam synthon. Its precise stereochemistry and functional groups make it a critical building block in the synthesis of novel cephalosporin antibiotics. This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in developing next-generation antibacterial agents and exploring new therapeutic pathways.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral synthon in the synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the R&D of new antibacterial drug candidates.
• Chemical Research: Used in academic and industrial laboratories for studying β-lactam chemistry and structure-activity relationships (SAR).
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for antibiotic production.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(6R-Cis)-3-(Hydroxymethyl)-7-Methoxy-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	54333-94-7
Molecular Formula	C16H16N2O6S2
Molecular Weight	396.44 g/mol
Synonyms	7-Methoxy-7-(2-thienylacetamido)-3-(hydroxymethyl)ceph-3-em-4-carboxylic Acid; (6R,7R)-7-Methoxy-3-(hydroxymethyl)-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-Methoxy-3-(hydroxymethyl)-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporin C Derivative; 7-ADCA Derivative; Thienylacetamido Cephem Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.