Description

6-Hydroxy-1,4,5,6-Tetrahydronicotinamide Adenine Dinucleotide is a specialized, high-purity biochemical cofactor essential for advanced enzymatic research and synthesis. This compound matters as a critical reagent in studying redox mechanisms and developing biocatalytic processes, offering researchers a reliable tool for precise metabolic pathway analysis. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and manufacturers of diagnostic enzymes and fine chemicals seeking to leverage nicotinamide cofactor chemistry.

Application

• Biocatalysis & Enzyme Engineering: As a co-substrate or cofactor in enzymatic reactions for the synthesis of chiral intermediates and active pharmaceutical ingredients (APIs).
• Metabolic Pathway Research: For in vitro studies of dehydrogenase enzymes and the investigation of cellular redox states and energy metabolism.
• Diagnostic Reagent Formulation: A key component in the manufacture of clinical diagnostic kits for measuring substrates like lactate, ethanol, or glycerol.
• Pharmaceutical R&D: Used in drug discovery platforms to screen for enzyme inhibitors or modulators targeting NAD(P)H-dependent pathways.
• Biochemical Assay Development: Serves as a standard or critical reagent in developing high-throughput screening (HTS) assays and analytical methods.
• Nutritional & Cosmetic Research: Investigated for its role in cellular energy production and anti-aging mechanisms in specialized research applications.

Basic Information

Product Name	6-Hydroxy-1,4,5,6-Tetrahydronicotinamide Adenine Dinucleotide
CAS No.	54298-36-1
Molecular Formula	C21H29N7O14P2
Molecular Weight	665.44 g/mol
Synonyms	6-Hydroxy-1,4,5,6-tetrahydro-NAD; 6-Hydroxy-1,4,5,6-tetrahydro-nicotinamide adenine dinucleotide; Reduced 6-Hydroxy-NAD; TH-NAD (6-OH); Dihydro-6-hydroxy-NAD; 1,4,5,6-Tetrahydro-6-hydroxy-NAD; 6-Hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-1,4,5,6-Tetrahydronicotinamide Adenine Dinucleotide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (Enzymatic)	≥ 90.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.