Description

(-)-Tetraphos CAS NO 54294-46-1 is a chiral, tetradentate phosphine ligand widely recognized for its utility in asymmetric catalysis. This compound matters for its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing optically pure intermediates and active pharmaceutical ingredients (APIs). Industries requiring advanced chiral synthesis, such as pharmaceutical R&D, fine chemical manufacturing, and academic research, need this high-performance ligand to develop novel compounds and optimize synthetic routes efficiently.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in enantioselective C-C and C-X bond-forming reactions.
• Key reagent for the synthesis of high-value, optically active fine chemicals and natural products.
• Use in academic and industrial research for developing new catalytic methodologies.
• Potential application in material science for creating chiral molecular frameworks.

Basic Information

Product Name	(-)-Tetraphos
CAS No.	54294-46-1
Molecular Formula	C52H44P4
Molecular Weight	804.82 g/mol
Synonyms	(-)-Tetraphos; (R,R,R,R)-Tetraphos; (R,R)-1,2-Bis[(R,R)-2,5-Dimethylphospholano]benzene; 1,2-Bis[(2R,5R)-2,5-dimethylphospholan-1-yl]benzene; (R,R)-Me-DuPhos analog tetradentate ligand; Chiral tetraphosphine ligand
EINECS	Contact for details

Quality Control

Our (-)-Tetraphos is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification and metal residue screening. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.