Description

Adriamycinol is a significant metabolite of the anthracycline antibiotic Doxorubicin, a key compound in pharmaceutical research and development. Its primary value lies in its role as a reference standard and active pharmaceutical ingredient (API) intermediate for studying drug metabolism, efficacy, and toxicity profiles. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors, particularly those focused on oncology drug development and pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of Doxorubicin and its metabolites in biological matrices.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic precursor in the research-scale production of anthracycline-based chemotherapeutic agents.
• Metabolite Profiling & Pharmacokinetic Studies: Essential for in vitro and in vivo studies to understand the metabolic pathways, bioavailability, and clearance of Doxorubicin.
• Biochemical Research: Employed in mechanistic studies to investigate the cardiotoxic effects and other side mechanisms associated with anthracycline therapy.
• Quality Control & Method Development: Utilized by analytical laboratories for developing and validating HPLC, LC-MS, and other chromatographic methods for impurity profiling.

Basic Information

Product Name	Adriamycinol
CAS No.	54193-28-1
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	Doxorubicinol; 13-Dihydrodoxorubicin; (7S,9S)-7-[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; 13-Hydroxydaunorubicin; Adriamycin metabolite; AD 32 metabolite; FI 106 metabolite
EINECS	Contact for details

Quality Control

Our Adriamycinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with in-house specifications. We support compliance with cGMP and ICH guidelines for API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Red-orange to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.