Description

Cyproheptadine 10,11-Epoxide is a key pharmaceutical intermediate and metabolite of the antihistamine drug cyproheptadine. This compound is of significant value in research and development for studying drug metabolism, pharmacokinetics, and for the synthesis of related active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in method development, impurity profiling, and reference standard production.

Application

• Pharmaceutical Intermediate: Used in the synthesis and research of cyproheptadine and its derivatives.
• Metabolite Reference Standard: Critical for analytical method development and validation in bioanalytical studies.
• Impurity Standard: Employed in quality control to identify and quantify related substances in drug substances and products.
• Pharmacokinetic Research: Serves as a standard in studies investigating the absorption, distribution, metabolism, and excretion (ADME) of cyproheptadine.
• Clinical Research: Used in studies to understand the metabolic pathways and efficacy of antihistaminic drugs.
• Regulatory Compliance: Supports regulatory filings by providing characterized impurities and degradation products as per ICH guidelines.

Basic Information

Product Name	Cyproheptadine 10,11-Epoxide
CAS No.	54191-04-7
Molecular Formula	C21H21NO
Molecular Weight	303.40 g/mol
Synonyms	10,11-Epoxycyproheptadine; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine 10,11-epoxide; Cyproheptadine epoxide; 1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine 10,11-oxide; NSC 169854; Periactin metabolite; Cyproheptadine 10,11-oxide
EINECS	Contact for details

Quality Control

Our Cyproheptadine 10,11-Epoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.