Description

Desmethylcyproheptadine 10,11-Epoxide is a key pharmaceutical intermediate and a metabolite of the antihistamine cyproheptadine. This compound is of significant value in research and development for studying drug metabolism, pharmacokinetics, and for the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers specializing in neuropharmacology and allergy-related therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced cyproheptadine analogs and related therapeutic compounds.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for quantifying drug metabolites in biological matrices.
• Pharmacology Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, efficacy, and safety profiles of antihistaminic drugs.
• Analytical Method Development: Serves as a high-purity standard for calibrating HPLC, LC-MS, and other chromatographic systems in quality control laboratories.
• Impurity Profiling: Employed to identify and quantify process-related impurities and degradation products in cyproheptadine API manufacturing.

Basic Information

Product Name	Desmethylcyproheptadine 10,11-Epoxide
CAS No.	54191-03-6
Molecular Formula	C₂₀H₂₀N₂O
Molecular Weight	304.39 g/mol
Synonyms	1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine 10,11-Epoxide; 10,11-Epoxy-10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-δ⁵⁺⁶-propylamine; Desmethylcyproheptadine Epoxide; Cyproheptadine Metabolite; 5H-Dibenzo[a,d]cyclohepten-5-one, 10,11-epoxy-10,11-dihydro-4-(1-methyl-4-piperidinylidene)-; 4-(10,11-Epoxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
EINECS	Contact for details

Quality Control

Our Desmethylcyproheptadine 10,11-Epoxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.