Description

1-Hydroxyibuprofen is a key pharmaceutical intermediate and an active metabolite of the widely used non-steroidal anti-inflammatory drug (NSAID) Ibuprofen. This compound is of significant interest in pharmaceutical research and development for its role in metabolic studies and as a precursor for advanced drug formulations. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, biotechnology, and fine chemical sectors engaged in anti-inflammatory drug development, pharmacokinetic analysis, and metabolite synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of novel NSAIDs and related therapeutic agents.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for pharmacokinetic and drug metabolism studies of Ibuprofen.
• Biochemical Research: Employed in enzymatic and metabolic pathway investigations to understand the biotransformation of Ibuprofen.
• Active Pharmaceutical Ingredient (API) Development: Serves as a starting material or key intermediate in the development of new drug formulations and prodrugs.
• Quality Control & Analytical Testing: Utilized by QC laboratories in pharmaceutical manufacturing for method development and validation.

Basic Information

Product Name	1-Hydroxyibuprofen
CAS No.	53949-53-4
Molecular Formula	C13H18O3
Molecular Weight	222.28 g/mol
Synonyms	1-Hydroxyibuprofen; 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid; (+/-)-1-Hydroxyibuprofen; Ibuprofen Hydroxy Metabolite; Ibuprofen, 1-hydroxy-; α-Methyl-4-(1-hydroxy-2-methylpropyl)benzeneacetic acid; IBU-OH; 1'-Hydroxyibuprofen
EINECS	Contact for details

Quality Control

Our 1-Hydroxyibuprofen is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.