Description

2-Bromobenzoylacetonitrile is a versatile brominated aromatic building block with significant utility in advanced organic synthesis. Its core value lies in its bifunctional reactivity, featuring both a bromoaryl group and an active methylene unit, which makes it a key intermediate for constructing complex heterocyclic and pharmaceutical scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of various drug candidates, particularly those containing benzofuran, quinoline, or other fused heterocyclic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic structure for bioactivity.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport molecules or nonlinear optical (NLO) chromophores.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying biological processes due to its reactive handles for bioconjugation.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, including cross-coupling and cyclization reactions.

Basic Information

Item	Detail
Product Name	2-Bromobenzoylacetonitrile
CAS No.	53882-80-7
Molecular Formula	C9H6BrNO
Molecular Weight	224.06 g/mol
Synonyms	2-Bromobenzoylacetonitrile; 3-Oxo-3-(2-bromophenyl)propanenitrile; (2-Bromobenzoyl)acetonitrile; 2-Bromo-ω-cyanacetophenone; α-Acetyl-2-bromobenzonitrile; 2-Bromophenacyl cyanide; 3-(2-Bromophenyl)-3-oxopropanenitrile
EINECS	Contact for details

Quality Control

Our 2-Bromobenzoylacetonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.