Description

1,3,5[10]-Estratriene-2,4-D2-3,17Beta-Diol is a deuterated derivative of estradiol, a key steroid hormone. This labeled compound is essential for research and development in pharmaceutical and analytical chemistry, providing a stable isotope tracer for metabolic and pharmacokinetic studies. It is primarily used by scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for advanced research applications.

Application

• Internal Standard for Mass Spectrometry: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS for the precise quantification of endogenous estradiol in complex biological matrices.
• Metabolic Pathway Tracing: Employed in deuterium tracing studies to investigate the metabolism, distribution, and excretion of estrogenic compounds.
• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in drug development and manufacturing.
• Biochemical Research: Utilized in receptor binding assays and studies of estrogen receptor (ER) interaction mechanisms.
• Diagnostic Kit Development: A critical component in the development of immunoassays and other diagnostic tests for hormonal analysis.

Basic Information

Product Name	1,3,5[10]-Estratriene-2,4-D2-3,17Beta-Diol
CAS No.	53866-33-4
Molecular Formula	C18H22D2O2
Molecular Weight	274.40 g/mol
Synonyms	Estradiol-2,4-D2; [2,4-D2]-Estradiol; 17β-Estradiol-2,4-D2; 3,17β-Dihydroxy-1,3,5(10)-estratriene-2,4-D2; E2-D2; Deuterated Estradiol; 1,3,5(10)-Estratriene-3,17β-diol-2,4-D2
EINECS	Contact for details

Quality Control

Our 1,3,5[10]-Estratriene-2,4-D2-3,17Beta-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and isotopic enrichment analysis. Certificates of Analysis (COA) with detailed chromatographic data and spectroscopic proof are provided to ensure compliance with research and pharmaceutical reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 97%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.