Description

16Alpha-Hydroxy-17Beta-Estradiol-2,4-D2 is a deuterated analog of a key estrogen metabolite, offering a stable isotopic label for advanced research and analytical applications. This compound is critical for precise quantification and metabolic pathway studies, providing superior accuracy over non-labeled standards. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories specializing in endocrinology, drug metabolism, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the sensitive and accurate quantification of estradiol and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracer studies to investigate the metabolic fate, bioavailability, and clearance pathways of steroid-based pharmaceuticals.
• Clinical Research & Diagnostics: Enables the development of robust assays for monitoring hormonal levels in clinical studies related to endocrinology, oncology, and reproductive health.
• Biomarker Discovery & Validation: Facilitates the precise measurement of estrogenic biomarkers in research focused on hormone-dependent conditions.
• Reference Standard for Quality Control: Acts as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating testing methods in GLP/GMP environments.

Basic Information

Item	Detail
Product Name	16Alpha-Hydroxy-17Beta-Estradiol-2,4-D2
CAS No.	53866-32-3
Molecular Formula	C18H22D2O3
Molecular Weight	290.40 g/mol
Synonyms	16α-Hydroxyestradiol-2,4-d2; Estra-1,3,5(10)-triene-3,16α,17β-triol-2,4-d2; [2,4-Dideutero]-16α-hydroxy-17β-estradiol; 16α-Hydroxy-17β-estradiol-2,4-dideuterio; Deuterated 16α-Hydroxyestradiol; 16α-OH-E2-d2
EINECS	Contact for details

Quality Control

Every batch of 16Alpha-Hydroxy-17Beta-Estradiol-2,4-D2 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, isotopic enrichment, and impurities is supplied with each shipment to ensure traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.