Description

n-Des(Dimethyl)-4-Epi-Tetracycline is a chemically modified tetracycline derivative, serving as a crucial intermediate in the synthesis of novel tetracycline-class antibiotics. This compound matters for its role in developing next-generation antimicrobial agents aimed at overcoming bacterial resistance. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antibiotic discovery and development programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of advanced tetracycline antibiotics, including sarecycline and other third-generation derivatives.
• Antibiotic Research & Development: Used in medicinal chemistry to create novel analogs with improved efficacy against resistant bacterial strains.
• Biochemical Research: Serves as a reference standard and tool compound for studying tetracycline biosynthesis pathways and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for producing specialized chemical entities with targeted biological activity.
• Academic Studies: Utilized in university and institutional research projects focused on microbiology and antibiotic mechanisms of action.

Basic Information

Product Name	n-Des(Dimethyl)-4-Epi-Tetracycline
CAS No.	53864-51-0
Molecular Formula	C₂₀H₂₂N₂O₈
Molecular Weight	418.40 g/mol
Synonyms	4-Epi-n-Desdimethyltetracycline; 4-Epi-NDDM-Tetracycline; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline; 4-Epianhydrodemeclocycline; 4-Epi-NDDM-TC; Tetracycline, 4-epi-n-desdimethyl-; Anhydro-4-epi-6-demethyl-6-deoxytetracycline
EINECS	Contact for details

Quality Control

Our n-Des(Dimethyl)-4-Epi-Tetracycline is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and synthesis applications. Quality is verified through comprehensive analytical testing, including HPLC for purity and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.