Description

4’-Hydroxy Trazodone β-D-Glucuronide is a high-purity reference standard and metabolite of the antidepressant trazodone. This compound is critical for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies for method development, bioanalytical validation, and clinical trial support.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of trazodone metabolites in biological matrices.
• Drug Metabolism Studies: Essential for investigating the metabolic pathways, pharmacokinetics, and bioavailability of trazodone in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating sensitive LC-MS/MS or HPLC methods for therapeutic drug monitoring (TDM).
• Forensic and Clinical Toxicology: Employed in laboratories to accurately identify and quantify trazodone and its metabolites in human plasma, serum, or urine samples.
• Impurity Profiling: Used in quality control laboratories to identify and characterize related substances and degradation products in trazodone drug substance and finished dosage forms.
• Academic Research: Utilized in universities and research institutes for pharmacological studies related to trazodone's mechanism of action and side-effect profile.

Basic Information

Product Name	4’-Hydroxy Trazodone β-D-Glucuronide
CAS No.	53818-11-4
Molecular Formula	C25H28N6O9
Molecular Weight	556.53 g/mol
Synonyms	4'-Hydroxytrazodone β-D-Glucuronide; Trazodone Metabolite m4 Glucuronide; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one 4'-O-β-D-Glucuronide; 1-[3-(4-m-Chlorophenyl-1-piperazinyl)propyl]-4-(β-D-glucopyranuronosyloxy)-s-triazolo[4,3-a]pyridin-5(4H)-one; Trazodone Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our 4’-Hydroxy Trazodone β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) with detailed chromatographic data and batch-specific results are provided to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.