Description

Trans -(E)-Flupenthixol CAS NO 53772-85-3 is a high-purity, stereochemically defined isomer of the typical antipsychotic agent flupentixol. This compound serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in neuropharmacological research and development. It is essential for analytical method development, quality control, and the synthesis of specialized pharmaceutical formulations. This product is primarily targeted at pharmaceutical R&D laboratories, analytical service providers, and manufacturers of active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of flupentixol-based drug products in compliance with pharmacopeial methods (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of the antipsychotic drug Flupentixol (Flupentixol).
• Neuropharmacology Research: Employed in preclinical and clinical studies to investigate the mechanism of action, pharmacokinetics, and metabolism of thioxanthene derivatives.
• Analytical Method Development: Serves as a pure calibrant for developing and validating HPLC, GC, and LC-MS/MS methods in quality control laboratories.
• Impurity Standard: Used to qualify and quantify isomeric and process-related impurities in bulk drug substances and finished formulations.
• Regulatory Submission Support: Provides certified material for stability studies, batch release testing, and regulatory documentation for drug master files (DMFs).

Basic Information

Product Name	Trans -(E)-Flupenthixol
CAS No.	53772-85-3
Molecular Formula	C₂₃H₂₅F₃N₂OS
Molecular Weight	434.52 g/mol
Synonyms	(E)-Flupentixol; trans-Flupentixol; Flupentixol, (E)-isomer; Flupenthixol; 2-Trifluoromethyl-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thioxanthene; α-Flupentixol; Emergil; Depixol; Fluanxol; Cisordinol; Metamin; 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol
EINECS	Contact for details

Quality Control

Our Trans -(E)-Flupenthixol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting the stringent requirements for pharmaceutical reference materials and intermediates. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from tests such as HPLC assay, chiral purity, residual solvents, and heavy metals. Our quality commitment aligns with cGMP principles to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Isomer Content)	≥99.0% (E)-isomer
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.