Description

Substance P (2-11) CAS NO 53749-61-4 is a defined fragment of the neuropeptide Substance P, specifically encompassing amino acid residues 2 through 11. This peptide is of significant value in biochemical and pharmacological research for studying the structure-activity relationships of Substance P and its receptor interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroscience, inflammation, and pain pathways.

Application

• Neuroscience Research: Used as a tool compound to investigate the role of Substance P in pain transmission, neurogenic inflammation, and central nervous system signaling.
• Pharmacological Studies: Employed in receptor binding assays and functional studies to map active sites and develop receptor antagonists or modulators.
• Biochemical Standard: Serves as a reference standard in analytical methods such as HPLC and mass spectrometry for peptide quantification and identification.
• Cell Biology & Immunology: Applied in studies exploring the interaction between the nervous and immune systems, particularly in models of inflammatory response.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits targeting Substance P-related biomarkers.

Basic Information

Product Name	Substance P (2-11)
CAS No.	53749-61-4
Molecular Formula	C58H86N16O13S
Molecular Weight	1231.5 g/mol
Synonyms	Substance P Fragment 2-11; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; SP (2-11); Neurokinin P (2-11); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; [Arg1, Pro2, Lys3, Pro4, Gln5, Gln6, Phe7, Phe8, Gly9, Leu10, Met11]-Substance P amide
EINECS	Contact for details

Quality Control

Our Substance P (2-11) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.