Description

Z-Trp-Nhme CAS NO 53708-61-5 is a protected amino acid derivative, specifically the Z-protected form of tryptophan methylamide. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), valued for its role in constructing complex peptides with high purity and defined sequences. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel therapeutic peptides, research biochemicals, and advanced diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of tryptophan residues in peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Serves as a modified amino acid for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry Libraries: Employed to generate diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Research: Essential for producing custom peptides used in structure-activity relationship (SAR) studies and mechanistic investigations.
• Diagnostic Reagent Development: Incorporated into synthetic peptides used as antigens, standards, or probes in immunoassays and diagnostic kits.

Basic Information

Product Name	Z-Trp-Nhme
CAS No.	53708-61-5
Molecular Formula	C₂₀H₂₁N₃O₃
Molecular Weight	351.40 g/mol
Synonyms	Nα-Carbobenzoxy-L-tryptophan N'-methylamide; Z-L-Tryptophan N-methylamide; CBZ-L-Tryptophan Methylamide; N-CBZ-L-Tryptophan Methylamide; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)-N-methylpropanamide; Benzyl N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]carbamate; Z-Trp-NHMe; CBZ-Trp-NHCH₃
EINECS	Contact for details

Quality Control

Our Z-Trp-Nhme is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring the material meets the stringent specifications required for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.