Description

4-[3-[6-Fluoro-2-(Trifluoromethyl)-9H-Thioxanthen-9-Yl]Propyl]Piperazine-1-Ethanol Dihydrochloride is a high-purity, non-racemic pharmaceutical intermediate and active ingredient. This compound is critical for its role in the synthesis of advanced therapeutic agents, particularly in neuropharmacology. It is primarily required by pharmaceutical R&D laboratories and manufacturers developing next-generation central nervous system (CNS) medications.

Application

• Key Intermediate in Antipsychotic Drug Synthesis: Serves as a crucial building block for the production of potent thioxanthene-derived neuroleptic agents.
• Pharmaceutical Active Pharmaceutical Ingredient (API): Used as the active moiety in formulated drug products targeting specific CNS receptors.
• Research & Development Reference Standard: Provides a high-purity standard for analytical method development, pharmacokinetic studies, and metabolic pathway research.
• Preclinical and Clinical Trial Material: Supplied under strict quality protocols for use in toxicology studies and various phases of clinical development.
• Process Chemistry and Route Scouting: Employed in the development and optimization of scalable synthetic routes for complex molecule manufacturing.

Basic Information

Product Name	4-[3-[6-Fluoro-2-(Trifluoromethyl)-9H-Thioxanthen-9-Yl]Propyl]Piperazine-1-Ethanol Dihydrochloride
CAS No.	53542-42-0
Molecular Formula	C23H25F4N3OS • 2HCl
Molecular Weight	548.44 g/mol (Free base: 475.53 g/mol)
Synonyms	Flupentixol Dihydrochloride; Flupentixol 2HCl; α-Flupentixol Dihydrochloride; 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-yl]propyl]-1-piperazineethanol dihydrochloride (Fluorinated); Cis(Z)-Flupentixol Dihydrochloride; Lu 5-110 Dihydrochloride; Depixol® (as salt form precursor); Fluanxol® (as salt form precursor)
EINECS	Contact for details

Quality Control

Our 4-[3-[6-Fluoro-2-(Trifluoromethyl)-9H-Thioxanthen-9-Yl]Propyl]Piperazine-1-Ethanol Dihydrochloride is manufactured under GMP-like conditions to ensure the highest standards of purity and consistency required for pharmaceutical applications. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent internal specifications aligned with ICH Q3A/B guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%
Optical Purity (Chiral HPLC)	≥99.0% (for specified enantiomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.