Description

Lithium 2-Methyl-2-Butoxide, also known as Lithium tert-Amylate, Lithium tert-Pentoxide, or Lithium tert-Pentyloxide, is a highly reactive organolithium compound and a powerful sterically hindered base. It is a critical reagent in advanced organic synthesis, valued for its ability to deprotonate weakly acidic substrates and initiate polymerization reactions under mild conditions. This chemical is essential for R&D and production in the pharmaceutical, agrochemical, and specialty polymer industries, where precise control over molecular structure is paramount.

Application

• Pharmaceutical Synthesis: As a key base in the production of active pharmaceutical ingredients (APIs), particularly for deprotonation steps in the synthesis of complex heterocycles and chiral molecules.
• Polymerization Initiator: Used as an anionic initiator for the controlled polymerization of monomers like styrene, dienes, and methacrylates to produce block copolymers and polymers with narrow molecular weight distributions.
• Agrochemical Intermediate: Employed in the synthesis of advanced herbicides, fungicides, and plant growth regulators where its strong basicity facilitates key bond-forming reactions.
• Fine Chemical & Catalyst Manufacturing: Serves as a precursor for other organometallic catalysts and reagents used in cross-coupling and other transition metal-catalyzed reactions.
• Material Science R&D: Utilized in the development of novel organic electronic materials, lithium-ion battery electrolytes, and advanced coatings.
• Academic & Industrial Research: A fundamental tool in methodological development and exploratory chemistry for creating new carbon-carbon and carbon-heteroatom bonds.

Basic Information

Product Name	Lithium 2-Methyl-2-Butoxide
CAS No.	53535-81-2
Molecular Formula	C5H11LiO
Molecular Weight	94.08 g/mol
Synonyms	Lithium tert-Amylate; Lithium tert-Pentoxide; Lithium tert-Pentyloxide; 2-Methyl-2-butanol lithium salt; Lithium 2-methylbutan-2-olate; tert-Amyl alcohol, lithium salt; tert-Pentyl alcohol, lithium salt; Lithium 1,1-dimethylpropoxide
EINECS	Contact for details

Quality Control

Our Lithium 2-Methyl-2-Butoxide is manufactured under stringent quality systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, alkali content, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support compliance with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly hygroscopic (moisture-sensitive) and pyrophoric nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C. Isolate from oxidizing agents, acids, and moisture.

Specification

Item	Specification
Appearance	White to off-white powder or lumps
Identification (IR)	Conforms
Assay (by Titration)	≥ 95.0%
Lithium (Li) Content	6.5 - 7.5 %
Solubility (in THF/Hexane)	Clear solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.