Description

1-Chloroisoquinoline-4-Carbonitrile is a versatile and high-value heterocyclic building block used in advanced organic synthesis. This compound is critical for the development of novel pharmaceuticals and agrochemicals due to its reactive chlorinated and nitrile functional groups. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a building block for creating functionalized polymers and advanced organic electronic materials.
• Chemical Synthesis: A versatile reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution.
• Academic & Contract Research: Essential for medicinal chemistry programs and discovery research in academic institutions and CROs.
• Dye & Pigment Intermediate: Used in the synthesis of specialized heterocyclic dyes and colorants.

Basic Information

Product Name	1-Chloroisoquinoline-4-Carbonitrile
CAS No.	53491-80-8
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	4-Cyano-1-chloroisoquinoline; 1-Chloro-4-cyanoisoquinoline; 1-Chloroisoquinoline-4-carbonitrile; Isoquinoline-4-carbonitrile, 1-chloro-; 1-Chloro-4-isoquinolinecarbonitrile; 53491-80-8; 1-Chloro-4-cyan-isoquinolin (German); 1-Chloro-4-cyano-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Chloroisoquinoline-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.